Events

Transposable element activation as a molecular cause of aging

Event date: 
23 October 2017 - 3:30pm
Location: 
Wallace Wurth C27 LG02
Event Type: 
Seminar
Booking deadline: 

Neuroscience & Non-Communicable Diseases SPECIAL SEMINAR

Prof Stephen Helfand, Brown University, USA

Stephen Helfand is recognized for his research on the molecular mechanisms underlying the process of aging, as well as the metabolic changes that occur with and contribute to the deleterious aspects of aging. His group began studying the molecular genetics of aging using Drosophila in 1992. Their initial work was directed at understanding the relationship between gene regulation and aging, and led to the discovery of one of the first longevity genes, Indy. Studying Indy led to an interest in mitochondrial physiology and metabolism, and in the mechanisms underlying life span extension by dietary restriction. In these studies they discovered the life span-extending effects of the histone deacetylases Rpd3 and Sir2, and of resveratrol, a small molecule activator of Sir2. More recently, his lab has explored the role of chromatin remodeling on gene expression during aging. This research led to their discovery of the relationship between the activity of retrotransposable elements and the deleterious phenotypes of aging. His research has consistently used the tools of Drosphila molecular genetics, high-throughput genome-wide approaches and bioinformatics

Contact for inquiries: 
Natasha Kumar Natasha.kumar@unsw.edu.au | Greg Smith g.smith@unsw.edu.au | Ingvars Birznie; i.birznieks@unsw.edu.au
Image - Transposable element activation as a molecular cause of aging

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24 July 2019

Room 305, Level 3, Samuels Building, UNSW Upper Campus, Kensington

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