A/Professor Jeff Holst
Head of the Translational Cancer Metabolism Laboratory, Adult Cancer Program, School of Medical Sciences, UNSW Sydney
Abstract: Amino acid transporters on cancer cells, so as to provide sufficient nutrients for the higher metabolic and growth demands of cancer cells. Over the past decade, our laboratory has studied a number of amino acid transporters, including L-type amino acid transporters (LAT1 and LAT3) and alanine-serine-cysteine transporter 2 (ASCT2) that mediate uptake of amino acids including leucine and glutamine. Leucine and glutamine are critical for the activity of mTORC1, which regulates protein translation and cell growth, as well as contributing to cellular energy, and as carbon and nitrogen donors for synthesis of DNA, RNA and protein.
Bio: Jeff completed his PhD at St Vincent’s Hospital/University of NSW and undertook postdoctoral studies at St Jude Children’s Research Hospital in the USA. He returned to Australia in 2006, starting a lab at the Centenary Institute, before relocating to the University of NSW in 2018. His recent work is focused on understanding the role of amino acid uptake and metabolism in melanoma, breast and prostate cancer. His lab examines the basic biology regulating amino acid transporter expression and function, the downstream metabolic pathways, as well as developing new therapeutics to target the transporters.
For information please contact: George Sharbeen.