Events

School of BABS Seminar Series - Exploiting cancer metabolism for drug discovery

Event date: 
13 July 2018 - 3:00pm
Location: 
Rountree Room 356, Level 3, Biological Sciences Building D26
Booking deadline: 

Exploiting Cancer metabolism for drug discover

Speaker: Dr Frances Byrne, Cancer Institure NSW Early Career Fellow

Seminar Outline:

This seminar will describe the development of a phenotypic drug screen to identify novel small molecules that alter cell metabolism and are selectively toxic to cancer cells. The basis for this drug screen was the knowledge that most genetic aberrations that initiate and promote cancer development in one way or another regulate cell metabolism. Not surprisingly, dysregulated metabolism is recognised as a hallmark of cancer and potential vulnerability by which to target cancer cells. From this screen a lead molecule was discovered that displays better cancer cell-specific toxicity than many frontline chemotherapy agents and molecules known to target cancer metabolism. Metabolomics and metabolic flux experiments helped determine how this molecule induces cancer cell death and selective toxicity. Working alongside medicinal chemists has led to the development of new molecules, with improved pharmacokinetics and oral bioavailability that may facilitate translational into the clinic.

Followed by Happy Hour in Wilton Tearoom 113, Level 1, Samuels Building F25

Image - School of BABS Seminar Series - Exploiting cancer metabolism for drug discovery

Calendar of Events

Su Mo Tu We Th Fr Sa
 
1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
9
 
10
 
11
 
12
 
13
 
14
 
15
 
16
 
17
 
18
 
19
 
20
 
21
 
22
 
23
 
24
 
25
 
26
 
27
 
28
 
29
 
30
 
31
 
 
 
 

24 July 2019

Room 305, Level 3, Samuels Building, UNSW Upper Campus, Kensington

Add your event

Submit your event to UNSW events. Only events run by UNSW will be accepted. Once approved your event will appear on both the UNSW and Medicine websites.

Add to UNSW Events

 

If your event has a local focus, submit your event to Medicine events. Only events run by Medicine will be accepted. Your event will only appear on Medicine websites. Do not use this if you have added your event to UNSW events.

Add to Medicine Events