Neuroscience & Non-Communicable Diseases Seminar Series
Speaker: Dr Adam de Graff, Methuselah Health UK Ltd, Cambridge, UK
Why do the damaging effects of oxidative metabolism harm some proteins but not others? Why are many disease-causing protein mutations of little consequence to the young, yet even the strongest alleles can give rise to disease when we are old?
This mysterious transition from robustness to frailty – from a genotype without a phenotype to a phenotype without a genotype – is central to aging and disease. Dr de Graff will describe how these mysteries all stem from how the cell’s proteostasis network collectively determines the folding status of its proteome and its susceptibility to oxidation. Rooted in basic protein biophysics, this model correctly predicts the classes of proteins most susceptible to damage, the temperature- and ROS-dependence of lifespan, and gives insight into the minimum protein intake needed for viability.
All welcome. Drinks and nibbles from 3:30pm, seminar starts, 4pm.