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Nanoformulations for cytokine sensing: from nanosensors to in vivo device development

Event date: 
21 March 2018 - 4:00pm to 5:00pm
Location: 
Kirby Seminar Space, Wallace Wurth C27
Booking deadline: 

Please join us for this fascinating talk which will be followed by light refreshments and conversation 
Abstract Cytokines secreted from cells play critical roles in tissue repair, cancer development and progression. Unfortunately, probing what cells “see”, and what they secrete as they respond in real time to the surrounding signals is still a major challenge. The ultra-low concentration of cytokine (in the pM range), and extremely dynamic, transient cytokine secretion process make cytokine quantification even difficult. By integrating with nanotechnology, biosensors as the analytical devices for the detection of an analyte, that combines a biological component with a physicochemical detector, have demonstrated huge potential for cytokine sensing. In this talk, Liu will summarize her recent research highlights on development of biosensors for detection of cytokines. Firstly, Liu will discuss the cell surface immunosensor for indentifying and selecting high cytokine-secreting cells. Then Liu’s talk will cover the study on the nanosensors for intracellular cytokine sensing. Finally, Liu will detail the development of in vivo biological detection devices for spatially localized cytokine monitoring in live rats. 
 About Guozhen Liu Dr Guozhen Liu, an ARC Future Fellow, has taken a role as a Senior Lecturer at the Graduate School of Biomedical Engineering, UNSW in 2018. Before that Dr Liu worked as an ARC Future Fellow at Macquarie University. Gaining her PhD degree in Chemistry in 2006 under the supervision of Prof Justin Gooding at UNSW, Dr Liu is recognised for her innovative cross-disciplinary research in the area of nanoscale analysis, nanotechnology, biosensors, and biomedical devices. Dr Liu conducted her postdoctoral research at CSIRO (2006-2008) and UNSW 
(2008-2010), respectively before she accepted a faculty position as Associate Professor at the Central China Normal University, China (2010-2015). In 2015 Dr Liu moved back to Sydney and worked as Research Fellow at ARC Centre of Excellence for Nanoscale Biophotonics (CNBP) at Macquarie University before she was awarded the ARC Future Fellowship in 2016. Dr Liu’s research career has alternated between industrial and academic research. Besides her several years’ academic research, Dr Liu also accumulated four years’ industrial experience as R&D Manager, China for AgaMatrix Inc. (2010-2015), the US based company for making diabetes products. Dr Liu has co-authored over 60 papers, 1 book chapter and 7 patents. The sensing technologies described in her patents have attracted the attention and investment of industry end-users, such as Medtronic and Regeneus Ltd. Dr Liu has attracted more than $2M in national and international research funding since 2015.  

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