Events

Modulating transposable genomic elements in germ cells, stem cells and ageing

Event date: 
29 June 2018 - 4:00pm
Location: 
Wallace Wurth LG02
File Attachment: 
School/Unit: 
Neuroscience & Non-Communicable Diseases
Booking deadline: 

A/Prof Shau-Ping Lin has over 25 years of research experience in reproductive biology, embryo development and epigenomic modulatory mechanisms in germ cells and stem cells. She identified the genomic imprinting control center (Nature Genetics, 2003b) for a developmentally necessary (Development, 2007), functional non-coding RNA containing (Nature Genetics, 2003a), Dlk1-Dio3 imprinted locus. Her recent work further indicated that the expression of long non-coding RNA (lncRNA), Meg3, and its associated downstream lncRNAs and microRNAs are critical for maintaining full neurological lineage differentiation potential in human pluripotent stem cells, and can reduce cancer formation risk in stem cell based therapy in regenerative medicine (Stem Cell Research & Therapy, 2015). Throughout the course of many studies, her lab also discovered that ectopic expression of DNA methyltransferase 3-like in aging somatic cells could introduce epigenetic reinforcement on aging related relaxation of developmentally regulated genes and retrotransposons, and thus bypass senescence (J Virology, 2014; manuscript in preparation).

All welcome. Drinks and nibbles from 3:30pm, seminar starts, 4pm.

Contact for inquiries: 
Neil Youngson, n.youngson@unsw.edu.au Natasha Kumar; Natasha.kumar@unsw.edu.au; Greg Smith; g.smith@unsw.edu.au
Image - Modulating transposable genomic elements in germ cells, stem cells and ageing

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19 October 2019

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