Events

High-Resolution Imaging of Multicellular Organisms - Srigokul Upadhyayula from Harvard Med School, Boston

Event date: 
15 June 2018 - 9:30am
Location: 
Wallace Wurth, level 6 seminar room 638
Event Type: 
Seminar
Booking deadline: 

True physiological imaging of subcellular features requires studying cells within their parent organisms, where all the environmental cues that drive gene expression, and hence the phenotypes we actually observe, are present. A complete understanding also requires volumetric imaging of the cell and its surroundings at high spatial and temporal resolution.  In the first half of my talk, I’ll discuss our recent work on combined lattice light sheet microscopy with two-channel adaptive optics to achieve, across large multicellular volumes, noninvasive aberration-free imaging of subcellular processes, including endocytosis, organelle remodeling during mitosis, and the migration of axons, immune cells, and metastatic cancer cells in vivo.  The technology reveals the phenotypic diversity within cells across different organisms and developmental stages and may offer insights into how cells harness their intrinsic variability to adapt to different physiological environments.  In the second half of my talk, I’ll present our data from an ongoing project aimed at high-resolution imaging of large tissue volumes. By combining the lattice light-sheet microscopy with the physical expansion and clearing capability of expansion microscopy, we demonstrate rapid nanoscale protein-specific imaging of cortical columns or whole brains.
 

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18 July 2019

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